13.1 POJA-L4687 + 4688 + La-0318 Elastic arteries in ageing (human)
13.1 POJA-L4687 + 4688 + La-0318
Title: Elastic arteries in ageing (human)
Description:
(A): Internal pudendal artery (penis), elastica (Masson) staining. Splitting of the internal elastic lamina (arrow) in the intima occurs during ageing. Note also cross-sectioned smooth muscle cells (SMC) (1) in the intima. (2) Media. (3) Adventitia with purple-red elastic fibres.
(B): Common carotid artery, azocarmine/light green staining. Elastic (conducting) arteries are also involved in atherosclerosis and show a sequela of characteristic events during the pathologic development. Degeneration processes in the thickened intima (1) with formation of deposits (2), degradation of ECM (3) and clusters of foam cells (4) precede atherosclerosis. (5) Media and adventitia (6).
(C1-C2): Aorta, Azan stain. With increasing age intimal changes start such as increase in elastic and collagen fibres resulting in thickening with some calcium deposits. Intima (1) with fragmentations of existing structures. Upper media (4) with dissolution of SMC and ECM, ‘foam’ cells (3) with trapped discrete lipid droplets and calcium precipitates. Note proliferation of SMC (lower [part of image).
Background: Splitting c.q. multiplication of the elastic lamina (arrow) in intima may occur during ageing or can be found on loci of arterial branching as well as in the tops of winding of vessels. It might be often the results of local adaptations of the vessel wall due to longitudinal tensions locally caused by the blood flow in those areas. From 20 years up fatty streaks in e.g. aorta, coronary arteries are the first signs of atherosclerosis. The first event in atherogenesis is an injured endothelium that can be triggered by e.g. trauma, changed laminar blood flow, hyperlipidemia, and hypertension. The presence of fatty streaks indicates a changed permeability of the arterial wall. They consist of lipid-loaded ‘foam’ cells beneath the lining endothelium. Gradually the streaks may regress, or remain stable or eventually evolve into atherosclerotic plaques. Generally, with increasing age intimal changes start in the large arteries (e.g. aorta) such as an increase in elastic and collagen fibres resulting in thickening of the intima. Deeper in the intimal layer more clusters of ‘foam’ cells are present.
Keywords/Mesh: cardiovascular system, vascularisation, blood vessel, elastic artery , muscular artery, internal elastic lamina, atherosclerosis, foam cell, histology, POJA collection
Title: Elastic arteries in ageing (human)
Description:
(A): Internal pudendal artery (penis), elastica (Masson) staining. Splitting of the internal elastic lamina (arrow) in the intima occurs during ageing. Note also cross-sectioned smooth muscle cells (SMC) (1) in the intima. (2) Media. (3) Adventitia with purple-red elastic fibres.
(B): Common carotid artery, azocarmine/light green staining. Elastic (conducting) arteries are also involved in atherosclerosis and show a sequela of characteristic events during the pathologic development. Degeneration processes in the thickened intima (1) with formation of deposits (2), degradation of ECM (3) and clusters of foam cells (4) precede atherosclerosis. (5) Media and adventitia (6).
(C1-C2): Aorta, Azan stain. With increasing age intimal changes start such as increase in elastic and collagen fibres resulting in thickening with some calcium deposits. Intima (1) with fragmentations of existing structures. Upper media (4) with dissolution of SMC and ECM, ‘foam’ cells (3) with trapped discrete lipid droplets and calcium precipitates. Note proliferation of SMC (lower [part of image).
Background: Splitting c.q. multiplication of the elastic lamina (arrow) in intima may occur during ageing or can be found on loci of arterial branching as well as in the tops of winding of vessels. It might be often the results of local adaptations of the vessel wall due to longitudinal tensions locally caused by the blood flow in those areas. From 20 years up fatty streaks in e.g. aorta, coronary arteries are the first signs of atherosclerosis. The first event in atherogenesis is an injured endothelium that can be triggered by e.g. trauma, changed laminar blood flow, hyperlipidemia, and hypertension. The presence of fatty streaks indicates a changed permeability of the arterial wall. They consist of lipid-loaded ‘foam’ cells beneath the lining endothelium. Gradually the streaks may regress, or remain stable or eventually evolve into atherosclerotic plaques. Generally, with increasing age intimal changes start in the large arteries (e.g. aorta) such as an increase in elastic and collagen fibres resulting in thickening of the intima. Deeper in the intimal layer more clusters of ‘foam’ cells are present.
Keywords/Mesh: cardiovascular system, vascularisation, blood vessel, elastic artery , muscular artery, internal elastic lamina, atherosclerosis, foam cell, histology, POJA collection