Title: “Flaming” plasma cell in peripheral blood smear (human)
Description: Stain: May-Grünwald-Giemsa (MGG).
The so called “flaming” plasma cell (1) is characterized by fiery fringes, which are formed by pseudopodic cytoplasmic projections (arrows) that stain with carmin red. These peripheral cytoplasmic spots contain numerous dilated endoplasmic reticulum cisterns, which are distended with immunoglobulin.
(2): Hypersegmented neutrophilic granulocyte.
Background: Due to secretory obstruction the Ig’s remain at the cell margin and ultimately destroy the cell (clasmatosis). “Flaming” plasma cells are seen associated with IgA myelomas as well as with reactive plasmacytosis.
Keywords/Mesh: blood, bone marrow, plasma cell, “flaming” plasma cell, IgG, myeloma, histology, POJA collection