Title: Toxic granulation and vacuolization in neutrophilic myelocytes in peripheral blood smear (human).
Description: Stain: May-Grünwald-Giemsa (MGG).
The myelocyte (1) and the metamyelocyte (2) show toxic granulation, vacuolisation and cytoplasmic swelling. Toxic granulation is characterized by violet-purple granules of varying size in the cytoplasm; generally admixed with normal pink granules.
The phenomenon occurs frequently at sepsis and other severe infections and toxic states as a result of denatured proteins in the cytoplasm i.e. rheumatoid arthritis or due to autophagocytosis within the cells The cytoplasm is partly basophilic, cloudy and contain vacuoles with generally a coarse granulation.
Keywords/Mesh: blood, bone marrow, myelocyte, neutrophil, toxic granulation, infection, sepsis, histology, POJA collection