Title: Lymphocyte (mature) (peripheral blood, human).
Description: Electron microscopy.
Mature B and T lymphocytes are ameboid cells (5-8 mm) with a high nucleus-cytoplasmic ratio. The cytoplasm contains a juxtanuclear Golgi area with centrioles (6), few large mitochondria (4). Profiles of rough endoplasmic reticulum (RER) (5) are sparsely present.
The surface exhibits short microvilli. Two to three small electron-dense granules are present (3). The nucleus (1) usually has a clear nucleolus (2) when activated.
Background: Lymphocytes are marked by CD-molecules or differentiation antigens (Cluster of Differentiation molecules), e.g. early stem cells carry CD34. B lymphocytes carry CD19 and CD20, while mature T lymphocytes carry CD3 (and CD4 or CD8) among other CD markers.
Keywords/Mesh: blood, bone marrow, lymphocyte, T cell, B cell, histology, electron microscopy, POJA collection