Title: Basophilic granulocyte (peripheral blood, human)
Description: Electron microscopy.
The detail shows close to the nucleus characteristic developing basophilic granules (specific granules) (8-13 mm).
At thin arrow (↓) a small Golgi area with a small specific granule.
At (***) granules with different osmiophilic internal structures. The basophilic granules vary in size and shape and are more regular granular-filamentous, in contrast to the myelin figure-like (scrolls-like) inclusions in the mast cell. All the granules contain among others, heparin, histamine, sulphated proteoglycans, leucotriene 3 etc.
Background: Exposure to allergens results in exocytosis of the granules, releasing e.g. histamine and other vasoactive mediators resulting in an anaphylactoid reaction (immediate hypersensitivity).
Keywords/Mesh: blood, bone marrow, basophilic granulocyte, specific granule, histamine, histology, electron microscopy, POJA collection