Title: Döhle bodies in mature neutrophils in peripheral blood smear (human)
Description: Stain: May-Grünwald-Giemsa (MGG).
In adults the usual response to a bacterial infection is a neutrophil leukocytosis with a “shift to the left”, toxic granulation, Döhle bodies and, when the infection is severe, cytoplasmic vacuolation and swelling occur.
Döhle bodies (1, arrow) are small, pale-blue-grey cytoplasmic inclusions, single or multiple, round or oval, often found towards the periphery of the cell. They are composed of stacks of endoplasmic reticulum (ribosomes) together with glycogen granules.
Döhle bodies are associated with pregnancy, infective and inflammatory states, burns and administration of cytokines such as G/M-CSF, myelodysplastic syndromes and some anomalies.
Keywords/Mesh: blood, bone marrow, neutrophil, Döhle body, histology, POJA collection