7.4 POJA-L1774+1780+1775. Metastasis (hematogenous) of invasive breast carcinoma (human)
7.4 POJA-L1774+1780+1775
Title: Metastasis (hematogenous) of invasive breast carcinoma (human)
Description: Stain: (A) Trichrome (Goldner); (B) Hematoxylin-eosin; (C) CK 7 (OVTL 12-30) antikeratin antibody immunoperoxidase staining with diaminobenzidin reaction (DAB) and hematoxylin counterstaining.
(A): Invasive carcinoma (1) with metastatic tumor cells (2) in hyalinized blood vessel flanked by two lymph vessels. Note at short distance invading small clumps of tumor cells in connective tissue area.
(B): Another area with disseminating tumor cells (1) and metastatic epitheloid tumor cell aggregation (2) in lumen of a hyalinized blood vessel.
(C): Tumor cells express a heterogeneous keratin 7 expression (1). Blood vessel in connection with a small branch and an embolus of aggregated keratin 7-positive cells (2). Note several strong-staining tumor cells between less reactive ones.
Background: The low-weight cytokeratin 7 is generally expressed by normal simple lining epithelia as well as by the epithelium of most serous/mucous glands. Terminal ductal lobular units (TDLU’s) distinctly express cytokeratin 7 (see also POJA-1773+1854+73 +2042+2043). The majority of malignant breast cancers are derived from the luminal cell lineage in the TDLU’s. During abnormal differentiation of these luminal cells CK 7 expression remains preserved and the neoplasms still preserve the common though often heterogeneous reactivity for CK 7. Therefore immunohistological detection (e.g. CK 7) of solitary or small clusters of tumor cells that infiltrate or metastasize via blood vessels is more easily and convincingly. Spread of the tumor eventually occurs through the lymphohematogenous routes. Although the main route for metastasis of breast carcinoma is primary via lymphatic invasion the transport via bloodstream occurs simultaneously. Distant metastases through the bloodstream may affect virtually any organ. Common secondary sites of breast cancer metastasis are: 1. bone, 2. lungs, 3. liver, 4. brain/ meninges, 5. adrenals.
Keywords/Mesh: breast, mammary glands, breast neoplasms, mammary carcinoma, histology, POJA collection, metastasis, cytokeratin 7
Title: Metastasis (hematogenous) of invasive breast carcinoma (human)
Description: Stain: (A) Trichrome (Goldner); (B) Hematoxylin-eosin; (C) CK 7 (OVTL 12-30) antikeratin antibody immunoperoxidase staining with diaminobenzidin reaction (DAB) and hematoxylin counterstaining.
(A): Invasive carcinoma (1) with metastatic tumor cells (2) in hyalinized blood vessel flanked by two lymph vessels. Note at short distance invading small clumps of tumor cells in connective tissue area.
(B): Another area with disseminating tumor cells (1) and metastatic epitheloid tumor cell aggregation (2) in lumen of a hyalinized blood vessel.
(C): Tumor cells express a heterogeneous keratin 7 expression (1). Blood vessel in connection with a small branch and an embolus of aggregated keratin 7-positive cells (2). Note several strong-staining tumor cells between less reactive ones.
Background: The low-weight cytokeratin 7 is generally expressed by normal simple lining epithelia as well as by the epithelium of most serous/mucous glands. Terminal ductal lobular units (TDLU’s) distinctly express cytokeratin 7 (see also POJA-1773+1854+73 +2042+2043). The majority of malignant breast cancers are derived from the luminal cell lineage in the TDLU’s. During abnormal differentiation of these luminal cells CK 7 expression remains preserved and the neoplasms still preserve the common though often heterogeneous reactivity for CK 7. Therefore immunohistological detection (e.g. CK 7) of solitary or small clusters of tumor cells that infiltrate or metastasize via blood vessels is more easily and convincingly. Spread of the tumor eventually occurs through the lymphohematogenous routes. Although the main route for metastasis of breast carcinoma is primary via lymphatic invasion the transport via bloodstream occurs simultaneously. Distant metastases through the bloodstream may affect virtually any organ. Common secondary sites of breast cancer metastasis are: 1. bone, 2. lungs, 3. liver, 4. brain/ meninges, 5. adrenals.
Keywords/Mesh: breast, mammary glands, breast neoplasms, mammary carcinoma, histology, POJA collection, metastasis, cytokeratin 7