7.4 POJA-L4194+4195+4196. Bone metastasis of invasive lobular breast carcinoma (human)
7.4 POJA-L4194+4195+4196
Title: Bone metastasis of invasive lobular breast carcinoma (human)
Description: Stain: (A, B) Hematoxylin-eosin; (C) Periodic acid Schiff (PAS).
(A, B): Low magnification with bone trabeculae. In this image osteoplasia is not depicted. Infiltrating small nests of packed tumor cells in stroma with fat cells replacing the bone marrow. Note that the malignant cells are small regular epithelial cells and show monomorphic moderately hyperchromatic nuclei. No tumor cell necrosis is observed. There is obviously no hematopoiesis. Bone tissue appears minimal affected.
(C): The PAS stain accentuates the solid tumor cell nests as their extracellular matrix (ECM) appears pink-reddish. The bony spicules also show stained-ECM in successive lamellae.
(By courtesy of F. van de Molengraft MD PhD, Department of Pathology, Rijnstate Hospital, Arnhem, The Netherlands).
Background: See also POJA- L-4197+4198+4199 and compare the different histologic appearance of both the tumors. Spread of the tumor eventually occurs through the lymphohematogenous routes. Distant metastases through the bloodstream may affect virtually any organ. Common secondary sites of breast cancer metastases are: 1. bone, 2. lungs, 3. liver, 4. brain/ meninges, 5. adrenals.
Keywords/Mesh: breast, mammary glands, bone, metastasis, breast neoplasms, mammary carcinoma, histology, POJA collection,
Title: Bone metastasis of invasive lobular breast carcinoma (human)
Description: Stain: (A, B) Hematoxylin-eosin; (C) Periodic acid Schiff (PAS).
(A, B): Low magnification with bone trabeculae. In this image osteoplasia is not depicted. Infiltrating small nests of packed tumor cells in stroma with fat cells replacing the bone marrow. Note that the malignant cells are small regular epithelial cells and show monomorphic moderately hyperchromatic nuclei. No tumor cell necrosis is observed. There is obviously no hematopoiesis. Bone tissue appears minimal affected.
(C): The PAS stain accentuates the solid tumor cell nests as their extracellular matrix (ECM) appears pink-reddish. The bony spicules also show stained-ECM in successive lamellae.
(By courtesy of F. van de Molengraft MD PhD, Department of Pathology, Rijnstate Hospital, Arnhem, The Netherlands).
Background: See also POJA- L-4197+4198+4199 and compare the different histologic appearance of both the tumors. Spread of the tumor eventually occurs through the lymphohematogenous routes. Distant metastases through the bloodstream may affect virtually any organ. Common secondary sites of breast cancer metastases are: 1. bone, 2. lungs, 3. liver, 4. brain/ meninges, 5. adrenals.
Keywords/Mesh: breast, mammary glands, bone, metastasis, breast neoplasms, mammary carcinoma, histology, POJA collection,