7.4 POJA-L4190+4191+4192
Title: Invasive lobular mamma carcinoma (ILC) (human)
Description: Stain: Hematoxylin-eosin.
(A): ILC with single files of poorly cohesive small atypical cells (‘Indian file’) (1) that infiltrate between the packed collagen fibers and surround in parallel arrays (2) a pre-existent lobule with calcification (3, reddish).
(B): ILC expands into neighbouring adipose tissue, tumor cells with monophormic light hyperchromatic nuclei show single-cell infiltration.
(C): Characteristic pattern of ILC i.e. with linear cords of infiltrating single tumor cells between collagen bundles (so-called ‘Indian file’ pattern (1). (*) fat cells.
(By courtesy of F. van de Molengraft MD PhD, Department of Pathology, Rijnstate Hospital, Arnhem, The Netherlands).
Background: Invasive lobular carcinoma (ILC) accounts for 10 % of all invasive carcinomas with an increased bilateral occurrence. About 60% of classic lobular carcinoma has associated carcinoma of the lobular type in situ (LCIS). A unique feature of ILC is that the amount of collagen increases resulting in a scirrhous macroscopic appearance. The tumor is composed of small, regular epithelial cells with mitoses sporadically. In the majority of the cases the tumor cells show no E-cadherin expression in contrast to invasive ductal carcinoma. Pattern of infiltration is diffuse, wide spread, characterized by single-cell infiltration and often in a single line arranged between collagen fibers. Variations are possible such as a more solid or alveolar growth pattern of the tumor cells. Classically single strings of cells infiltrate between collagen fibers giving rise to the ‘Indian file’ pattern.
Keywords/Mesh: breast, mammary glands, breast neoplasms, mammary carcinoma, histology, POJA collection, invasion
Title: Invasive lobular mamma carcinoma (ILC) (human)
Description: Stain: Hematoxylin-eosin.
(A): ILC with single files of poorly cohesive small atypical cells (‘Indian file’) (1) that infiltrate between the packed collagen fibers and surround in parallel arrays (2) a pre-existent lobule with calcification (3, reddish).
(B): ILC expands into neighbouring adipose tissue, tumor cells with monophormic light hyperchromatic nuclei show single-cell infiltration.
(C): Characteristic pattern of ILC i.e. with linear cords of infiltrating single tumor cells between collagen bundles (so-called ‘Indian file’ pattern (1). (*) fat cells.
(By courtesy of F. van de Molengraft MD PhD, Department of Pathology, Rijnstate Hospital, Arnhem, The Netherlands).
Background: Invasive lobular carcinoma (ILC) accounts for 10 % of all invasive carcinomas with an increased bilateral occurrence. About 60% of classic lobular carcinoma has associated carcinoma of the lobular type in situ (LCIS). A unique feature of ILC is that the amount of collagen increases resulting in a scirrhous macroscopic appearance. The tumor is composed of small, regular epithelial cells with mitoses sporadically. In the majority of the cases the tumor cells show no E-cadherin expression in contrast to invasive ductal carcinoma. Pattern of infiltration is diffuse, wide spread, characterized by single-cell infiltration and often in a single line arranged between collagen fibers. Variations are possible such as a more solid or alveolar growth pattern of the tumor cells. Classically single strings of cells infiltrate between collagen fibers giving rise to the ‘Indian file’ pattern.
Keywords/Mesh: breast, mammary glands, breast neoplasms, mammary carcinoma, histology, POJA collection, invasion