Description: Scheme electron microscopy.
The large promyelocyte (15-25 mm) contains a nucleus (1) with one or two nucleoli, the rough endoplasmic reticulum (4) is present and show many expanded profiles. Distinct also are numerous ribosomes and a well-developed Golgi area (2) where ‘non-specific’, primary or azurophilic granules (3, here with different densities) are formed. These granules contain among others myeloperoxidase, acid phosphatase and arylsulfatase.
Background: From CFU-S (colony forming units-spleen) stem cells arise CFU-GM (colony forming unit-granulocyte/monocyte) stem cells. The latter divide by mitoses and differentiate via promyeloblasts, myeloblasts and promyelocytes into myelocytes (the last proliferative stage).
Keywords/Mesh: blood, bone marrow, promyelocyte, azurophilic granule, lysosome, histology, electron microscopy, POJA collection