4.1.1 POJA-L1083+1084. GALT and Peyer’s patches in the ileum (human, dog)
4.1.1 POJA-L-1083+1084
Title: GALT and Peyer’s patches in the ileum (human, dog)
Description: Stain: Azan, (A, dog; B, human).
The mucosa of the ileum is folded into villi (1) and crypts (2). In the lamina propria and in the tela submucosa solitary lymphatic nodules occur as Peyer’s patches (3). The lymph nodes can be active and expand towards the epithelium where lymphocytes migrate from the lamina propria into the epithelium (B, arrows,↘↘) and even can “dissolve” the epithelial layers.
The Peyer’s patches can transport luminal antigens and bacteria and thus induce immune tolerance or defense against pathogens. The intestinal epithelium and the gut-associated lymphoid tissue (GALT) interact with each other. Specialized M cells (microfold cells) transport the luminal antigens to the lymphoid cells in the Peyer’s patches where FDC’s (follicular dendritic cells), NODs (nucleotide oligomerisation domains) and IgA production and receptors are thought to be crucial factors in the regulation of the local immune response.
Keywords/Mesh: ileum, Peyer’s patches, lymphoid tissue, small intestine, lymphoid follicles, histology, POJA collection
Title: GALT and Peyer’s patches in the ileum (human, dog)
Description: Stain: Azan, (A, dog; B, human).
The mucosa of the ileum is folded into villi (1) and crypts (2). In the lamina propria and in the tela submucosa solitary lymphatic nodules occur as Peyer’s patches (3). The lymph nodes can be active and expand towards the epithelium where lymphocytes migrate from the lamina propria into the epithelium (B, arrows,↘↘) and even can “dissolve” the epithelial layers.
The Peyer’s patches can transport luminal antigens and bacteria and thus induce immune tolerance or defense against pathogens. The intestinal epithelium and the gut-associated lymphoid tissue (GALT) interact with each other. Specialized M cells (microfold cells) transport the luminal antigens to the lymphoid cells in the Peyer’s patches where FDC’s (follicular dendritic cells), NODs (nucleotide oligomerisation domains) and IgA production and receptors are thought to be crucial factors in the regulation of the local immune response.
Keywords/Mesh: ileum, Peyer’s patches, lymphoid tissue, small intestine, lymphoid follicles, histology, POJA collection