13.1 POJA-La0082+0088 Renin production in vascular smooth muscle cells (kidney)
13.1 POJA-La0082+0088
Title: Renin production in vascular smooth muscle cells (kidney)
Description:
(A): Afferent arteriole, EM, rat resp. toad. Electron micrograph of a glomerulus with afferent arteriole (lumen, 1). The modified granular smooth muscle cells (2) are located in the wall (media) of afferent arterioles at the vascular hilum of the glomerulus. The JG cell contains dense renin granules.
(B): Immunogold labeling of renin secretion granules using gold particles labeled anti-renin antibodies. (By courtesy of A. Lamers PhD, Dept. Cell Biology).
The other renal cell types such as podocytes, mesangium cells are not marked here.
Background: Juxtaglomerular (JG) cells are highly specialised non-contractile smooth muscle cells in the afferent arteriole of the kidney. These granular JG cells secrete the hormone renin in response to osmotic and pressure changes, and is involved in the tubuloglomerular regulation of glomerular filtration. Renin in turn activates the renin-angiotensin system to regulate blood pressure. (For more images see POJA Collection Microscopic Anatomy Section 5.1 Urinary System)
Keywords/Mesh: cardiovascular system, vascularisation, kidney, glomerulus, arteriole, vas afferens, juxtaglomerular cell, histology, POJA collection
Title: Renin production in vascular smooth muscle cells (kidney)
Description:
(A): Afferent arteriole, EM, rat resp. toad. Electron micrograph of a glomerulus with afferent arteriole (lumen, 1). The modified granular smooth muscle cells (2) are located in the wall (media) of afferent arterioles at the vascular hilum of the glomerulus. The JG cell contains dense renin granules.
(B): Immunogold labeling of renin secretion granules using gold particles labeled anti-renin antibodies. (By courtesy of A. Lamers PhD, Dept. Cell Biology).
The other renal cell types such as podocytes, mesangium cells are not marked here.
Background: Juxtaglomerular (JG) cells are highly specialised non-contractile smooth muscle cells in the afferent arteriole of the kidney. These granular JG cells secrete the hormone renin in response to osmotic and pressure changes, and is involved in the tubuloglomerular regulation of glomerular filtration. Renin in turn activates the renin-angiotensin system to regulate blood pressure. (For more images see POJA Collection Microscopic Anatomy Section 5.1 Urinary System)
Keywords/Mesh: cardiovascular system, vascularisation, kidney, glomerulus, arteriole, vas afferens, juxtaglomerular cell, histology, POJA collection