7.1 POJA-L1471+1478+1757. Papillary serous cystadenocarcinoma of ovary (human, adult)
7.1 POJA-L1471+1478+1757
Title: Papillary serous cystadenocarcinoma of ovary (human, adult)
Description: Stain: (A, B) Hematoxylin-eosin; (C) CK7 (OVTL12/30) antikeratin antibody immunoperoxidase staining with diaminobenzidin reaction (DAB) and hematoxylin counterstaining.
(A): Low magnification of papillary processes (1) covered by epithelium showing extensive proliferation.
(B): Higher magnification shows that single rows of columnar cells form multilayering. (2). There is variation in nuclear hyperchromatism and irregular tufting is present (*).
(C): Lining epithelium remains reactive for CK7. Underlying stroma with venules is negative (3). One venule (4) contains a dense-stained CK7-positive metastatic tumor cell. (Partly by courtesy of G. P. Vooijs MD, PhD, former Head of the Department of Pathology, Radboud university medical center, Nijmegen, The Netherlands).
Background: Histogenetically it is assumed that a majority of epithelial tumors of the ovary is derived from the ovarian serosa. This lining is the equivalent of the embryonic coelomic epithelium in adulthood. Embryologically the coelomic epithelium give rise to the müllerian epithelium (ducts of Müller) and its derivates are the fallopian tube lining (tubal pathway), endometrial lining (endometrial pathway) and endocervical glands lining (endocervical pathway). The ovarian surface epithelium contains undifferentiated cells that still possess the potency to differentiate along similar embryonic pathways. In this way a tumor derived from these cells can differentiate in a similar way. They arise either directly from that epithelium or from epithelial nests that are sequestrated into the cortex. Epithelial tumors that differentiate along the above-mentioned tubal pathway are formed by the group of serous tumors. Serous cystadenocarcinomas are essentially a malignant form of serous cystadenomas; they account for ca. 40% of all ovarian cancers and appear to be the most common malignant tumors. Mostly they are bilaterally and occurring later in life than benign and borderline tumors which usually are found between 20 and 50 years. The size of malignant serous tumors varies between 10 and 15 cm up to sometimes 40 cm diameters. With hemorrhagic foci, the tumors are mostly cystic but also partially solid. The fibrous cysts are lined by tubal-like columnar, often ciliated cells and contain blood-stained serous fluid. Solid areas of the tumor are composed of closely packed papillae that might penetrate the tumor capsule. Luxuriant papillomatous growths also extend over the surface and obliterate the ovarian structure. Destructive infiltrative stromal invasion is evident as the tumor ingrowth is diffuse or as solid cell sheets. Psammoma bodies (calcified concrements) though not specific might be present, too. Normal simple lining epithelia as well as the epithelium of most mucous or serous glands generally express cytokeratin 7. Ovarian surface epithelial cells are also positive for the low molecular weight keratin protein cytokeratin 7. During abnormal differentiation of these epithelial cells CK7 expression remains preserved. Individual tumor cells of well-differentiated adenocarcinomas metastasize via blood vessels or by invasion. Application of a.o. low-molecular weight keratins such as CK7 allows histological detection of solitary tumor cells more easily and convincingly.
Keywords/Mesh: female reproductive organs, ovary, serous cystadenocarcinoma, female genitalia, , ovarian neoplasms, keratin 7, OVTL12/30 antibody, metastasis, tumor, histology, POJA collection
Title: Papillary serous cystadenocarcinoma of ovary (human, adult)
Description: Stain: (A, B) Hematoxylin-eosin; (C) CK7 (OVTL12/30) antikeratin antibody immunoperoxidase staining with diaminobenzidin reaction (DAB) and hematoxylin counterstaining.
(A): Low magnification of papillary processes (1) covered by epithelium showing extensive proliferation.
(B): Higher magnification shows that single rows of columnar cells form multilayering. (2). There is variation in nuclear hyperchromatism and irregular tufting is present (*).
(C): Lining epithelium remains reactive for CK7. Underlying stroma with venules is negative (3). One venule (4) contains a dense-stained CK7-positive metastatic tumor cell. (Partly by courtesy of G. P. Vooijs MD, PhD, former Head of the Department of Pathology, Radboud university medical center, Nijmegen, The Netherlands).
Background: Histogenetically it is assumed that a majority of epithelial tumors of the ovary is derived from the ovarian serosa. This lining is the equivalent of the embryonic coelomic epithelium in adulthood. Embryologically the coelomic epithelium give rise to the müllerian epithelium (ducts of Müller) and its derivates are the fallopian tube lining (tubal pathway), endometrial lining (endometrial pathway) and endocervical glands lining (endocervical pathway). The ovarian surface epithelium contains undifferentiated cells that still possess the potency to differentiate along similar embryonic pathways. In this way a tumor derived from these cells can differentiate in a similar way. They arise either directly from that epithelium or from epithelial nests that are sequestrated into the cortex. Epithelial tumors that differentiate along the above-mentioned tubal pathway are formed by the group of serous tumors. Serous cystadenocarcinomas are essentially a malignant form of serous cystadenomas; they account for ca. 40% of all ovarian cancers and appear to be the most common malignant tumors. Mostly they are bilaterally and occurring later in life than benign and borderline tumors which usually are found between 20 and 50 years. The size of malignant serous tumors varies between 10 and 15 cm up to sometimes 40 cm diameters. With hemorrhagic foci, the tumors are mostly cystic but also partially solid. The fibrous cysts are lined by tubal-like columnar, often ciliated cells and contain blood-stained serous fluid. Solid areas of the tumor are composed of closely packed papillae that might penetrate the tumor capsule. Luxuriant papillomatous growths also extend over the surface and obliterate the ovarian structure. Destructive infiltrative stromal invasion is evident as the tumor ingrowth is diffuse or as solid cell sheets. Psammoma bodies (calcified concrements) though not specific might be present, too. Normal simple lining epithelia as well as the epithelium of most mucous or serous glands generally express cytokeratin 7. Ovarian surface epithelial cells are also positive for the low molecular weight keratin protein cytokeratin 7. During abnormal differentiation of these epithelial cells CK7 expression remains preserved. Individual tumor cells of well-differentiated adenocarcinomas metastasize via blood vessels or by invasion. Application of a.o. low-molecular weight keratins such as CK7 allows histological detection of solitary tumor cells more easily and convincingly.
Keywords/Mesh: female reproductive organs, ovary, serous cystadenocarcinoma, female genitalia, , ovarian neoplasms, keratin 7, OVTL12/30 antibody, metastasis, tumor, histology, POJA collection