Title: Megakaryocyt in bone marrow smear (human)
Description: Stain: May-Grünwald-Giemsa (MGG), (black and white print).
The giant polyploid cell (35-160 mm) contains a large multilobate nucleus. Note the ring-like pattern of the nuclei (1).
The light-stained perinuclear zone (2) contains Golgi areas, within the encompassing greyish (intermediate) zone (3) granules and organelles are present. They represent future platelet formations. The light-stained peripheral area (marginal zone) (4) contains cytoskeletal elements. This large cell is surrounded by many developing small-sized blood cells.
Background: This cell is derived from a promegakaryocyte, a descendens from CFU-S (colony forming units-spleen) stem cells via CFU-Mega (colony forming unit-megakaryocyte) stem cells.
Keywords/Mesh: blood, bone marrow, megakaryocyte, platelet, histology, POJA collection