1.1 POJA-L809. Megakaryocyt in bone marrow smear (human

return to blood & bone marrow images

 1.1  POJA-L809

Title: Megakaryocyt in bone marrow smear (human)
 
Description: Stain: May-Grünwald-Giemsa  (MGG), (black and white print).

The giant polyploid cell (35-160 mm) contains a large multilobate nucleus. Note the ring-like pattern of the nuclei (1).
The light-stained perinuclear zone (2) contains Golgi areas, within the encompassing greyish (intermediate) zone (3) granules and organelles are present. They represent future platelet formations. The light-stained peripheral area (marginal zone) (4) contains cytoskeletal elements. This large cell is surrounded by many developing small-sized blood cells.

Background: This cell is derived from a promegakaryocyte, a descendens from CFU-S (colony forming units-spleen) stem cells via CFU-Mega (colony forming unit-megakaryocyte) stem cells.
 
Keywords/Mesh: blood, bone marrow, megakaryocyte, platelet, histology, POJA collection