14.1 POJA-L6037+6038 Histochemistry IV Phosphorylase activity in control and denervated skeletal muscle
14.1 POJA-L6037+6038 Histochemistry IV skeletal muscle, Phosphorylase activity
14.1 POJA-L6037+6038 Histochemistry IV Phosphorylase activity in control and denervated skeletal muscle
Title: Histochemistry IV Phosphorylase activity in control and denervated skeletal muscle
Description:
(A): Phosphorylase activity in control mouse.
(B): Phosphorylase activity in denervated skeletal muscle of the mouse. Histochemically, type II fibers appear to lose the enzyme activity.
Glycogen synthase or phosphorylase is involved in the breakdown of glycogen storage into glucose. Denervation of skeletal muscles induces severe muscle atrophy, which is preceded by cellular alterations such as increased plasma membrane permeability and accelerated protein catabolism and breakdown of muscle fibres (Cisterna, B.A., Vargas, A.A., Puebla, C. et al. Active acetylcholine receptors prevent the atrophy of skeletal muscles and favour reinnervation. Nat Commun 11, 1073 (2020). https://doi.org/10.1038/s41467-019-14063-8).
Denervation causes a decrease in insulin-stimulated glucose uptake and a decline of phosphorylase activity. There is a loss in the ability of insulin to stimulate glycogen synthesis due to a post-receptor defect.
Keywords/Mesh: locomotor system, skeletal muscle, striated muscle, phosphorylase, glycogen, denervation, glycogenolysis, insulin, histochemistry, POJA collection
Description:
(A): Phosphorylase activity in control mouse.
(B): Phosphorylase activity in denervated skeletal muscle of the mouse. Histochemically, type II fibers appear to lose the enzyme activity.
Glycogen synthase or phosphorylase is involved in the breakdown of glycogen storage into glucose. Denervation of skeletal muscles induces severe muscle atrophy, which is preceded by cellular alterations such as increased plasma membrane permeability and accelerated protein catabolism and breakdown of muscle fibres (Cisterna, B.A., Vargas, A.A., Puebla, C. et al. Active acetylcholine receptors prevent the atrophy of skeletal muscles and favour reinnervation. Nat Commun 11, 1073 (2020). https://doi.org/10.1038/s41467-019-14063-8).
Denervation causes a decrease in insulin-stimulated glucose uptake and a decline of phosphorylase activity. There is a loss in the ability of insulin to stimulate glycogen synthesis due to a post-receptor defect.
Keywords/Mesh: locomotor system, skeletal muscle, striated muscle, phosphorylase, glycogen, denervation, glycogenolysis, insulin, histochemistry, POJA collection