7.1 POJA-L1347+1574+1447+1448+1618. Sequential events during follicular atresia in ovary (human)
7.1 POJA-L1347+1574+1447+1448+1618
Title: Sequential events during follicular atresia in ovary (human)
Description: Stain: (A, E) Azan; (B, C, D Trichrome (Goldner).
(A): Atretic follicles are degenerating follicles and if atresia occurs in an antral stage the oocyte degenerates. At (1) atretic antral follicle with coagulated follicular fluid without any lining granulosa cells. Locally remnants of theca cells (2) are still present and ingrowth of connective tissue at (3). At (arrow) thickened basement membrane (membrana vitrea).
(B): Part of an atretic follicle. Due to collapse of the antrum the basement membrane (membrana vitrea) between former granulosa cells and theca layers transforms into a thick, wavy band, the so-called glassy membrane (arrow). Fibrous tissue ingrowth at (3).
(C): The glassy membrane transforms into a thick, wavy and hyalinized band (arrow) interwoven with proliferating fibrous tissue from outwards. Former central cavity of follicle (1) with ingrowing connective tissue.
(D): In a more advanced stage, dense accumulations of hyalinized membranes (arrow) are packed. They are composed of acellular collagenous tissue. Ovarian stroma and blood vessels surround the packed membranes.
(E): In the process of atresia, the continuous shrinkage of the twirl hyalineous band-like structures results in a small fibrotic scar (corpus fibrosum, corpus atreticum). Once surrounded by cell-rich ovarian stroma it usually merges with ovarian stroma and disappears.
Background: Not all follicles fully develop. Many are lost at various stages of development due to the process of atresia. If atresia occurs at an early stage the follicles e.g. primary follicles completely disappear. If the process occurs at a later stage e.g. antral follicles the oocyte degenerates. Surrounded by proliferating connective tissue small fibrotic scars (corpora fibrosa, atretica) or even small cysts are the results. They are mostly pushed towards the medulla and merge within the ovarian stroma.
Keywords/Mesh: female reproductive organs, ovary, follicular atresia, corpus atreticum, female genitalia, histology, POJA collection
Title: Sequential events during follicular atresia in ovary (human)
Description: Stain: (A, E) Azan; (B, C, D Trichrome (Goldner).
(A): Atretic follicles are degenerating follicles and if atresia occurs in an antral stage the oocyte degenerates. At (1) atretic antral follicle with coagulated follicular fluid without any lining granulosa cells. Locally remnants of theca cells (2) are still present and ingrowth of connective tissue at (3). At (arrow) thickened basement membrane (membrana vitrea).
(B): Part of an atretic follicle. Due to collapse of the antrum the basement membrane (membrana vitrea) between former granulosa cells and theca layers transforms into a thick, wavy band, the so-called glassy membrane (arrow). Fibrous tissue ingrowth at (3).
(C): The glassy membrane transforms into a thick, wavy and hyalinized band (arrow) interwoven with proliferating fibrous tissue from outwards. Former central cavity of follicle (1) with ingrowing connective tissue.
(D): In a more advanced stage, dense accumulations of hyalinized membranes (arrow) are packed. They are composed of acellular collagenous tissue. Ovarian stroma and blood vessels surround the packed membranes.
(E): In the process of atresia, the continuous shrinkage of the twirl hyalineous band-like structures results in a small fibrotic scar (corpus fibrosum, corpus atreticum). Once surrounded by cell-rich ovarian stroma it usually merges with ovarian stroma and disappears.
Background: Not all follicles fully develop. Many are lost at various stages of development due to the process of atresia. If atresia occurs at an early stage the follicles e.g. primary follicles completely disappear. If the process occurs at a later stage e.g. antral follicles the oocyte degenerates. Surrounded by proliferating connective tissue small fibrotic scars (corpora fibrosa, atretica) or even small cysts are the results. They are mostly pushed towards the medulla and merge within the ovarian stroma.
Keywords/Mesh: female reproductive organs, ovary, follicular atresia, corpus atreticum, female genitalia, histology, POJA collection