1.1 POJA-L644. Lymphoblast (spleen, rat)

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1.1  POJA-L644 

Title: Lymphoblast (spleen, rat)
 
Description: Electron microscopy.

Interspersed between small lymphocytes the lymphoblast with a high nucleus-cytoplasm ratio is a larger cell with a distinct nucleolus. The cytoplasm is studded with numerous polysomes and ribosomes, only few mitochondria and a single strand of rough endoplasmic reticulum are present.

Background: A lymphoid progenitor cell divides to produce two types of lymphoid stem cells. One type migrates to the thymus, proliferates and differentiates into T lymphocytes. The other type remains in the bone marrow or settles in the spleen and lymph nodes where it proliferates into lymphoblasts that in turn divide and eventually become immunocompetent B lymphocytes (in follicles). Dependent on the appropriate stimulation the latter cells might differentiate via plasmablasts into plasma cells.
 
Keywords/Mesh:  blood, bone marrow, lymphoblast, histology,  electron microscopy, POJA collection