Title: Clear cell carcinoma, vagina (human, adult)
Description: Stain: (A, B) Hematoxylin-eosin; (C) CK 7 (OVTL 12-30) antikeratin 7 antibody immunoperoxidase staining with diaminobenzidin reaction (DAB).
(A): Survey of tumor that partly is growing papillary (1), adenomatous (2) and tubulocystic (3); the tumor is infiltrating deep into the vagina wall (4).
(B): Atypic polymorphic cells are localized in solid tubulocystic formations (3) of proliferation. Venule at right side (V).
(C): Heterogeneous expression of keratin 7 (OVTL 12-30) of acinar tumor cells in solid pattern. Note some dark-stained cells, so-called ‘hobnail’ cells (→) lining lumina (*) in atypic acini. (Partly by courtesy of G. P. Vooijs MD PhD, former Head of the Department of Pathology, Radboud university medical center, Nijmegen, The Netherlands).
Clinical background: Clear cell carcinomas appear macroscopically as ulcerous and sometimes bleeding proliferating polyps on the anterior and lateral vaginal walls and could even fill up the whole vaginal lumen. These tumors frequently expand towards the anterior cervical wall. The tumors are well vascularized and might expose hemorrhagic areas, necroses as well as areas of chronic and acute inflammations. Tumor cells tend to spread to the environment and metastasize to regional lymph nodes.
Keywords/Mesh: female reproductive organs, vagina, clear cell carcinoma, keratin 7, vaginal neoplasm, clear cell adenocarcinoma, histology, POJA collection.