16.1.3 POJA-L7022+7071+7070 Calcification process in bone 1
16.1.3 POJA-L7022+7071+7070 Calcification process in bone 1
16.1.3 POJA-L7022+7071+7070 Calcification process in bone 1
Title: Calcification process in bone 1
Description:
(A, B) Rat. (C) Gerbil.
(1): Osteoblast.
(2): Subosteoblast layer.
(3): Bone matrix.
(4): Collagen fibrils.
(5): Hydroxyapatite (HA).
(Arrows) point to vesicles of varying sizes with small HA crystals.
Background:
In bone tissue complete conversion of phosphate and calcium to hydroxyapatite occurs. Osteoblasts actively transport phosphate, which is converted from pyrophosphate or nucleotide phosphates by alkaline phosphatase and other phosphatases. Hydroxyapatite is organised, in part, by accessory proteins, but the process of crystallisation generates massive amounts of acid. For a detailed review on the mechanism see:
Osteoblast Differentiation and Bone Matrix Formation In Vivo and In Vitro. Harry C. Blair, MD,1,,2 Quitterie C. Larrouture, MS,2 Yanan Li, MD, PhD,3 Hang Lin, PhD,4 Donna Beer-Stoltz, PhD,2 Li Liu, MD, PhD,2 Rocky S. Tuan, PhD,4 Lisa J. Robinson, MD,5,,6 Paul H. Schlesinger, MD, PhD,7 and Deborah J. Nelson, PhD8.
Tissue Eng Part B Rev. 2017 Jun 1; 23(3): 268–280. doi: 10.1089/ten.teb.2016.0454
See also:
Keywords/Mesh: locomotor system, bone, calcification, osteoblast, collagen, hydroxyapatite, POJA collection, electron microscopy
Title: Calcification process in bone 1
Description:
(A, B) Rat. (C) Gerbil.
(1): Osteoblast.
(2): Subosteoblast layer.
(3): Bone matrix.
(4): Collagen fibrils.
(5): Hydroxyapatite (HA).
(Arrows) point to vesicles of varying sizes with small HA crystals.
Background:
In bone tissue complete conversion of phosphate and calcium to hydroxyapatite occurs. Osteoblasts actively transport phosphate, which is converted from pyrophosphate or nucleotide phosphates by alkaline phosphatase and other phosphatases. Hydroxyapatite is organised, in part, by accessory proteins, but the process of crystallisation generates massive amounts of acid. For a detailed review on the mechanism see:
Osteoblast Differentiation and Bone Matrix Formation In Vivo and In Vitro. Harry C. Blair, MD,1,,2 Quitterie C. Larrouture, MS,2 Yanan Li, MD, PhD,3 Hang Lin, PhD,4 Donna Beer-Stoltz, PhD,2 Li Liu, MD, PhD,2 Rocky S. Tuan, PhD,4 Lisa J. Robinson, MD,5,,6 Paul H. Schlesinger, MD, PhD,7 and Deborah J. Nelson, PhD8.
Tissue Eng Part B Rev. 2017 Jun 1; 23(3): 268–280. doi: 10.1089/ten.teb.2016.0454
See also:
Keywords/Mesh: locomotor system, bone, calcification, osteoblast, collagen, hydroxyapatite, POJA collection, electron microscopy