4.2.1 POJA-L3791+3792+3793. Examples of nuclear deviations in cellular pathology of the liver (human)
4.2.1 POJA-L-3791+3792+3793
Title: Examples of nuclear deviations in cellular pathology of the liver (human)
Description: Stain: (A) PAS. (B) Goldner. (C) Electron micrograph.
(A) Shows nuclear inclusions in the liver of a patient with active rheuma. The intense pink stained cytoplasm reveals glycogen content.
(B) Nuclear inclusions in obstetric liver atrophy. The intranuclear inclusion bodies are surrounded by a clear halo (CMV inclusion body). (C) Nuclear inclusions (arrow).
Background: Inclusion bodies are nuclear or cytoplasmic aggregates of stainable substances, usually proteins. They typically represent sites of viral multiplication in the cell and usually consist of viral capsid proteins. Inclusion bodies also occur in genetic diseases like Parkinson’s disease. It is reported that the production of protein aggregates specifically targeted to either the nucleus or cytosol leads to global impairment of UPS (ubiquitin-proteasome system) function in both cellular compartments.
Keywords/Mesh: liver, nuclear inclusions, cholestasis, electron microscopy, histology, POJA collection
Title: Examples of nuclear deviations in cellular pathology of the liver (human)
Description: Stain: (A) PAS. (B) Goldner. (C) Electron micrograph.
(A) Shows nuclear inclusions in the liver of a patient with active rheuma. The intense pink stained cytoplasm reveals glycogen content.
(B) Nuclear inclusions in obstetric liver atrophy. The intranuclear inclusion bodies are surrounded by a clear halo (CMV inclusion body). (C) Nuclear inclusions (arrow).
Background: Inclusion bodies are nuclear or cytoplasmic aggregates of stainable substances, usually proteins. They typically represent sites of viral multiplication in the cell and usually consist of viral capsid proteins. Inclusion bodies also occur in genetic diseases like Parkinson’s disease. It is reported that the production of protein aggregates specifically targeted to either the nucleus or cytosol leads to global impairment of UPS (ubiquitin-proteasome system) function in both cellular compartments.
Keywords/Mesh: liver, nuclear inclusions, cholestasis, electron microscopy, histology, POJA collection