1.1 POJA-L645+646. Lymphocyte (peripheral blood, human)

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1.1  POJA-L645+646

Title: Lymphocyte (peripheral blood, human)
 
Description: Electron microscopy.

(Cytotoxic) lymphocyte (A) with a juxtanuclear Golgi area (3) and centrioles (2), few mitochondria (4) and sparsely profiles of rough endoplasmic reticulum (RER). Dense-stained granules (1) are present. The surface exhibits short blunt microvilli.

The right lymphocyte in (B) has similar characteristics but cytotoxic granules are not visible.
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(5): Platelets.

Background: Cytolytic lymphocytes, i.e. NK-cells and cytotoxic T cells, recognize by different receptors (MHC-I, CD’s) antigens on infected cells and kill these cells with the content of the granules. The membrane-bound cytoplasmic granules contain proteins, including perforin and granzymes. In addition, differentiated CTL’s (cytotoxic lymphocytes), like Th1 cells are capable of secreting cytokines, mostle IFN-γ, lymphotoxin, and TNF which function to activate phagocytes and induce inflammation.
 
Keywords/Mesh:  blood, bone marrow, lymphocyte, T cell, histology, electron microscopy, POJA collection