1.1 POJA-L749. Plasmablast

1.1  POJA-L749

Title: Plasmablast
 
Description: Scheme electron microscopy.

This plasmablast (up to 20 mm) shows an indented large nucleus (1) and a distinct nucleolus (2).
In addition to free ribosomes long profiles of rough endoplasmic reticulum (RER) (3) are being developed concomitant with Golgi packages (4).
The cytoplasm is scanty with few organelles. In light microscopy the principal characteristic is the distinct basophilia of its cytoplasm (RER).

​Background:
​A pluripotent hematopoietic stem cell gives rise to a common lymphoid progenitor cell. The latter divides to produce two types of lymphoid stem cells. One type migrates to the thymus, proliferates and differentiates into T lymphocytes. The other type (pre-B cell) remains in the bone marrow or settles in the spleen, lymph nodes where it proliferates into lymphoblasts that in turn divide and eventually result in immunocompetent B lymphocytes. Dependent on the appropriate stimulation B lymphocytes can be activated to divide and differentiate via plasmablasts into antibody-secreting plasma cells (plasmacytes).
 
Keywords/Mesh: blood, bone marrow, plasmablast, plasma cell, histology, electron microscopy, POJA collection