7.4 POJA-L4193+237. Invasive breast carcinoma (human)
7.4 POJA-L4193+237
Title: Invasive breast carcinoma (human)
Description: Stain: (A) Hematoxylin-eosin; (B) CK 7 (OVTL 12-30) antikeratin antibody immunoperoxidase staining with diaminobenzidin reaction (DAB) and hematoxylin counterstaining.
(A): Disordered infiltration of invasive carcinoma of no special type (NST); a mix of sheets and tight clumps of tumor cells extends into adipose tissue.
(B): A heterogeneous reactivity for keratin 7 in tumor cells and in between large non-stained adipocytes.
(By courtesy of F. van de Molengraft MD PhD, Department of Pathology, Rijnstate Hospital, Arnhem, The Netherlands).
Background: A vast majority of breast cancers are thought to arise within the terminal duct lobular units (TDLUs) as well as in the ducts (extralobular/subsegmental/segmental ones). Most of the malignant tumors are derived from the luminal cells. They are divided into noninvasive (or in situ carcinomas) and invasive carcinomas. The most common types of invasive breast carcinoma are infiltrating ductal carcinoma (no special type), infiltrating lobular carcinoma, and in lesser amounts tubular/cribriform and medullary carcinomas. The mucoid and papillary carcinomas are rare. Grade of differentiation and tumor type correlate well with prognosis, e.g. infiltrating ductal carcinoma has a relatively poor prognosis while infiltrating lobular carcinoma has an intermediate prognosis. Cytokeratin 7 is generally expressed by normal simple lining epithelia as well as by the epithelium of most serous/mucous glands. Terminal ductal lobular units (TDLU’s) distinctly express CK 7 (see POJA-L-1773+1854+73+2042+2043) and therefore neoplasms originating from them still preserve the common but often heterogeneous reactivity for CK 7. Exceptions of simple lining in human that do not express overall CK 7 are a.o. lining cells of large intestine (colonocytes). As a result adenocarcinomas of colonic origin remain CK7-negative and application of antibodies against low-weight keratins such as CK 7 allows detection and discrimination between colon carcinomas and breast neoplasms i.e. between their metastases subsequently.
Keywords/Mesh: breast, mammary glands, breast neoplasms, invasive breast carcinoma, ductal carcinoma, cytokeratin 7,
Title: Invasive breast carcinoma (human)
Description: Stain: (A) Hematoxylin-eosin; (B) CK 7 (OVTL 12-30) antikeratin antibody immunoperoxidase staining with diaminobenzidin reaction (DAB) and hematoxylin counterstaining.
(A): Disordered infiltration of invasive carcinoma of no special type (NST); a mix of sheets and tight clumps of tumor cells extends into adipose tissue.
(B): A heterogeneous reactivity for keratin 7 in tumor cells and in between large non-stained adipocytes.
(By courtesy of F. van de Molengraft MD PhD, Department of Pathology, Rijnstate Hospital, Arnhem, The Netherlands).
Background: A vast majority of breast cancers are thought to arise within the terminal duct lobular units (TDLUs) as well as in the ducts (extralobular/subsegmental/segmental ones). Most of the malignant tumors are derived from the luminal cells. They are divided into noninvasive (or in situ carcinomas) and invasive carcinomas. The most common types of invasive breast carcinoma are infiltrating ductal carcinoma (no special type), infiltrating lobular carcinoma, and in lesser amounts tubular/cribriform and medullary carcinomas. The mucoid and papillary carcinomas are rare. Grade of differentiation and tumor type correlate well with prognosis, e.g. infiltrating ductal carcinoma has a relatively poor prognosis while infiltrating lobular carcinoma has an intermediate prognosis. Cytokeratin 7 is generally expressed by normal simple lining epithelia as well as by the epithelium of most serous/mucous glands. Terminal ductal lobular units (TDLU’s) distinctly express CK 7 (see POJA-L-1773+1854+73+2042+2043) and therefore neoplasms originating from them still preserve the common but often heterogeneous reactivity for CK 7. Exceptions of simple lining in human that do not express overall CK 7 are a.o. lining cells of large intestine (colonocytes). As a result adenocarcinomas of colonic origin remain CK7-negative and application of antibodies against low-weight keratins such as CK 7 allows detection and discrimination between colon carcinomas and breast neoplasms i.e. between their metastases subsequently.
Keywords/Mesh: breast, mammary glands, breast neoplasms, invasive breast carcinoma, ductal carcinoma, cytokeratin 7,