14.6 POJA-L6335+6336 Autophagic vacuoles (human)
14.6 POJA-L6335+6336 Autophagic vacuoles
14.6 POJA-L6335+6336 Autophagic vacuoles (human)
(By courtesy of L. Eshuis BSc Section Electron microscopy, Department of Pathology, Radboud university medical center, Nijmegen, The Netherlands)
Title: Autophagic vacuoles (human)
Description:
(A): Note that the regular rows of normal mitochondria are displaced. Arrows indicate replacement by accumulation of autophagic vacuoles (a case of colchicine intoxication).
(B): Detail of this colchicine myopathy demonstrates dense stained dispersed and aggregated glycogen granules and some relicts of mitochondria with cristae.
Colchicine-induced myopathy is an autophagic, vacuolar myopathy that occurs as a rare complication of treatment with colchicine. The fusion of autophagosome with lysosomes involves the sarcoplasmic microtubular system. Destabilisation and disruption of the microtubules occurs after administration of colchicine. Impaired fusion of the lysosomal vesicles leads to aggregation of autophagic vacuoles.
See also:
Keywords/Mesh: locomotor system, skeletal muscle, striated muscle, myopathy, colchicine, autophagic vacuole, mitochondrion, glycogen, electron microscopy, pathology, POJA collection
Title: Autophagic vacuoles (human)
Description:
(A): Note that the regular rows of normal mitochondria are displaced. Arrows indicate replacement by accumulation of autophagic vacuoles (a case of colchicine intoxication).
(B): Detail of this colchicine myopathy demonstrates dense stained dispersed and aggregated glycogen granules and some relicts of mitochondria with cristae.
Colchicine-induced myopathy is an autophagic, vacuolar myopathy that occurs as a rare complication of treatment with colchicine. The fusion of autophagosome with lysosomes involves the sarcoplasmic microtubular system. Destabilisation and disruption of the microtubules occurs after administration of colchicine. Impaired fusion of the lysosomal vesicles leads to aggregation of autophagic vacuoles.
See also:
- 14.1 POJA-L6316+6317+6246 Autophagic vacuoles in striated muscle
- 14.1.2. POJA-L6321+6320+6322 Autophagy in myopathy
Keywords/Mesh: locomotor system, skeletal muscle, striated muscle, myopathy, colchicine, autophagic vacuole, mitochondrion, glycogen, electron microscopy, pathology, POJA collection