4.1.1 POJA-L4174+4175+4176
Title: Endocrine cells in the epithelium of the colon (human)
Description: Stain: (A) Anti-serotonin (5-HT) monoclonal antibody immunoperoxidase staining with DAB and hematoxylin counterstaining. (B) Immunoperoxidase staining with CO-TL1 monoclonal antibody against colon-specific antigen with DAB and hematoxylin counterstaining. (C) Electron micrograph of an endocrine cell with small electron dense endocrine granules located between the nucleus and basal membrane.
Arrows in (A and B) (↘) indicate the endocrine cells usually located in the deeper area of the colon crypts.
Note in (B) that the epitope recognized by the CO-TL1 antibody is present in both the endocrine and the normal epithelial cell types of the colon.
Serotonin, released by the enterochromaffin cells, binds to 5-HT(3) and 5-HT(4) receptors which are involved in regulation of intestinal motility and secretory reflexes.
Keywords/Mesh: colon, endocrine cells, serotonin, CO-TL1, electron microscopy, histology, POJA collection
Title: Endocrine cells in the epithelium of the colon (human)
Description: Stain: (A) Anti-serotonin (5-HT) monoclonal antibody immunoperoxidase staining with DAB and hematoxylin counterstaining. (B) Immunoperoxidase staining with CO-TL1 monoclonal antibody against colon-specific antigen with DAB and hematoxylin counterstaining. (C) Electron micrograph of an endocrine cell with small electron dense endocrine granules located between the nucleus and basal membrane.
Arrows in (A and B) (↘) indicate the endocrine cells usually located in the deeper area of the colon crypts.
Note in (B) that the epitope recognized by the CO-TL1 antibody is present in both the endocrine and the normal epithelial cell types of the colon.
Serotonin, released by the enterochromaffin cells, binds to 5-HT(3) and 5-HT(4) receptors which are involved in regulation of intestinal motility and secretory reflexes.
Keywords/Mesh: colon, endocrine cells, serotonin, CO-TL1, electron microscopy, histology, POJA collection