1.1 POJA-L732
Title: Plasma cell Description: Scheme electron microscopy. The mature plasma cell or plasmacyte (12-15 mm) shows an excentric nucleus (1) with a characteristic chunky distribution of heterochromatin along the inner nuclear membrane (“spoke-wheel” effect in light microscopy). Juxtanuclearly an elaborate Golgi area (2) with secretion vacuoles together with centrioles (3) are often present (cytocenter). The cytoplasma is packed with long profiles of rough endoplasmic reticulum (RER) (4) with in between several mitochondria (5) confirming the secretory activity. Dependent on the cellular activity the RER vary from small or distended up to dilated profiles, in light microscopy this results in the deep basophilia of the cytoplasm and the light-stained centrosome (so-called nuclear “hof”). |
Background:
A pluripotent hematopoietic stem cell gives rise to a common lymphoid progenitor cell. The latter divides to produce two types of lymphoid stem cells. One type migrates to the thymus, proliferates and differentiates into T lymphocytes. The other type remains in the bone marrow or settles in the spleen, lymph nodes where it proliferates into lymphoblasts that in turn divide and eventually result in immunocompetent B lymphocytes. Dependent on the appropriate stimulation B lymphocytes can be activated to divide and differentiate via plasmablasts into antibody-secreting plasma cells (plasmacytes).
A revised concept of the structure of the endoplasmic reticulum is published in: Science. 2016 Oct 28;354(6311). pii: aaf3928. Epub 2016 Oct 27
Keywords/Mesh: blood, bone marrow, plasmablast, plasma cell, histology, electron microscopy, POJA collection
A pluripotent hematopoietic stem cell gives rise to a common lymphoid progenitor cell. The latter divides to produce two types of lymphoid stem cells. One type migrates to the thymus, proliferates and differentiates into T lymphocytes. The other type remains in the bone marrow or settles in the spleen, lymph nodes where it proliferates into lymphoblasts that in turn divide and eventually result in immunocompetent B lymphocytes. Dependent on the appropriate stimulation B lymphocytes can be activated to divide and differentiate via plasmablasts into antibody-secreting plasma cells (plasmacytes).
A revised concept of the structure of the endoplasmic reticulum is published in: Science. 2016 Oct 28;354(6311). pii: aaf3928. Epub 2016 Oct 27
Keywords/Mesh: blood, bone marrow, plasmablast, plasma cell, histology, electron microscopy, POJA collection