14.6 POJA-L6300 + 6300-CCC
(By courtesy of P. Poels MD, PhD , neurologist, (Dept. Neurology Radboud university medical center, Nijmegen, The Netherlands and H. ter Laak PhD Section Neuropathology, retired staff member Department of Pathology, Radboud university medical center, Nijmegen, The Netherlands)
Title: Rhabdomyolysis II (human)
Trichrome staining. Rhabdomyolysis. The Trichrome stained section shows several stages of both necrosis and regenerating muscle fibres occurring concomitantly. The central myofibre (1) shows evidence of necrosis by the presence of vacuoles and the presence of small grainy red structures, e.g., cytoplasmic bodies. These bodies are derived from abnormally arranged Z-band material. They are common in several types of myositis (e.g., inclusion body myositis IBM).
A small regenerated muscle fibre (3) and a thickened capillary (red arrow) are present.
The myofibre (2) shows focal disruption of the sarcoplasm indicating early signs of degeneration and necrosis. (3) is another regenerated fibre and two red arrows point to nucleated structures (possibly young myotubes) close to other flanking smaller regenerated fibres (yellow frame).
The yellow rectangle in POJA-L6300 is enlarged in POJA-L6300-CCC.
Within the maturing regenerated fibre (*) a centrally located nucleus with distinct nucleolus (1) displays the presence of a small myotube. At (2, 3) most probably nuclei of the late fibre remained surrounded by fluffy threadlike sarcoplasmic remnants of the necrosis. In the periphery of regenerating fibres small clear areas (5) contain PAS-positive substance e.g., glycogen as demonstrated in (14.6 POJA-L-6282+6280+6267+6265+6278+6272 Histochemical profile of Rhabdomyolysis I).
(4): The larger normal myofibres present abundant purple dots indicating mitochondria.
Keywords/Mesh: locomotor system, skeletal muscle, striated muscle, neuromuscular disease, myopathy, rhabdomyolysis, necrosis, degeneration, pathology, POJA collection