4.2.1 POJA-L3690+3703+3776+3775. Augmentation of peroxisomes in alcoholic liver hepatitis (human)
4.2.1 POJA-L3690+3703+3776+3775
Title: Augmentation of peroxisomes in alcoholic liver hepatitis (human)
Description: Electron micrographs show four examples where the number of peroxisomes has been increased considerably.
(A) Rat, one week after hepatectomy.
(B) Rat, after auxiliary liver transplantation.
(C, D) Human, patients with alcoholic hepatitis.
Background: Peroxisomes do have a key function in several crucial metabolic processes such as β-oxidation of fatty acids, biosynthesis of ether phospholipids and metabolism of reactive oxygen species. They carry more than 50 enzymes for those activities. The peroxisomes detoxify various toxic molecules that enter the bloodstream. About 25% of the ethanol we drink is oxidized to acetaldehyde in this way. The considerable increase in the number of peroxisomes in alcoholic hepatitis is caused by the alcohol intake. In the samples (A, B) the augmentation has probably to do with general required increase for detoxification process.
Keywords/Mesh: liver, peroxisomes, alcoholic hepatitis, electron microscopy, histology, POJA collection
Title: Augmentation of peroxisomes in alcoholic liver hepatitis (human)
Description: Electron micrographs show four examples where the number of peroxisomes has been increased considerably.
(A) Rat, one week after hepatectomy.
(B) Rat, after auxiliary liver transplantation.
(C, D) Human, patients with alcoholic hepatitis.
Background: Peroxisomes do have a key function in several crucial metabolic processes such as β-oxidation of fatty acids, biosynthesis of ether phospholipids and metabolism of reactive oxygen species. They carry more than 50 enzymes for those activities. The peroxisomes detoxify various toxic molecules that enter the bloodstream. About 25% of the ethanol we drink is oxidized to acetaldehyde in this way. The considerable increase in the number of peroxisomes in alcoholic hepatitis is caused by the alcohol intake. In the samples (A, B) the augmentation has probably to do with general required increase for detoxification process.
Keywords/Mesh: liver, peroxisomes, alcoholic hepatitis, electron microscopy, histology, POJA collection