7.4 POJA-L4197+4198+4199. Bone metastasis of squamous cell carcinoma of unknown origin (human)
7.4 POJA-L4197+4198+4199
Title: Bone metastasis of squamous cell carcinoma of unknown origin (human)
Description: Stain: (A, B, C) Hematoxylin-eosin.
(A): Bone trabecle (1) with artificial cleft due to preparation procedures. Malignant cells (2) grow in pseudoductal forms and multinucleated cells are present.
(B, C): Local bone resorption (arrows); and atypical polygonal cells showing sometimes desmosomes (zoom into cell clusters). Tumor cells grow in pseudoductal as well as in stratified forms, small nest of epithelial pearl formation is present. Focally dyskeratosis, mitoses and large cells with pleomorphic nuclei and multinucleated cells are present. Most likely it is a metastasis of a squamous cell carcinoma of the lungs.
(By courtesy of F. van de Molengraft MD PhD, Department of Pathology, Rijnstate Hospital, Arnhem, The Netherlands).
Background: See also POJA-L-4194+4195+4196 and compare the different histologic appearance of both tumors. Spread of a tumor eventually occurs through the lymphohematogenous routes. Distant metastases through the bloodstream may affect virtually any organ. Metastases in bones and liver are common for lung carcinomas and widespread metastases may be found from a clinically silent, small bronchial carcinoma. Even at autopsy it appears very difficult to find the primary tumor.
Keywords/Mesh: bone, metastasis, squamous cell carcinoma, pseudoductal, dyskeratosis, histology, POJA collection
Title: Bone metastasis of squamous cell carcinoma of unknown origin (human)
Description: Stain: (A, B, C) Hematoxylin-eosin.
(A): Bone trabecle (1) with artificial cleft due to preparation procedures. Malignant cells (2) grow in pseudoductal forms and multinucleated cells are present.
(B, C): Local bone resorption (arrows); and atypical polygonal cells showing sometimes desmosomes (zoom into cell clusters). Tumor cells grow in pseudoductal as well as in stratified forms, small nest of epithelial pearl formation is present. Focally dyskeratosis, mitoses and large cells with pleomorphic nuclei and multinucleated cells are present. Most likely it is a metastasis of a squamous cell carcinoma of the lungs.
(By courtesy of F. van de Molengraft MD PhD, Department of Pathology, Rijnstate Hospital, Arnhem, The Netherlands).
Background: See also POJA-L-4194+4195+4196 and compare the different histologic appearance of both tumors. Spread of a tumor eventually occurs through the lymphohematogenous routes. Distant metastases through the bloodstream may affect virtually any organ. Metastases in bones and liver are common for lung carcinomas and widespread metastases may be found from a clinically silent, small bronchial carcinoma. Even at autopsy it appears very difficult to find the primary tumor.
Keywords/Mesh: bone, metastasis, squamous cell carcinoma, pseudoductal, dyskeratosis, histology, POJA collection