9.9 POJA-L3853+3854+3855
Title: Chromophobe adenoma of the hypophysis or pituitary adenoma
Description:
(A - C): Adenoma, stain hematoxylin-eosin, human. The polygonal cells are relatively uniform (cellular monomorphism) and are arranged
in cords or sheaths with spare connective tissue. The absence of significant reticulum network distinguishes the tumor from normal
pituitary anterior parenchyma.
Based on tinctorial properties the following classification is made:
(a) acidophil adenoma producing growth hormone (acromegaly) and/or prolactin (prolactinoma);
(b) basophil adenoma (producing ACTH or LH or FSH) (overproduction of cortisol, Cushing disease);
(c) chromophobe adenoma which do not secrete hormones (e.g. non-functioning tumors).
Nowadays, the pathological classification of pituitary adenomas is based on the hormone content of the tumors using immuno-histochemical staining with antibodies.
(Stained sections kindly provided by P. Wesseling MD PhD, Head Neuropathology, Department of Pathology, Radboud university medical center, Nijmegen, The Netherlands)
Keywords/Mesh: adrenocortical adenoma, adrenal gland, pituitary, chromophobe adenoma, histology, pathology, POJA collection
Title: Chromophobe adenoma of the hypophysis or pituitary adenoma
Description:
(A - C): Adenoma, stain hematoxylin-eosin, human. The polygonal cells are relatively uniform (cellular monomorphism) and are arranged
in cords or sheaths with spare connective tissue. The absence of significant reticulum network distinguishes the tumor from normal
pituitary anterior parenchyma.
Based on tinctorial properties the following classification is made:
(a) acidophil adenoma producing growth hormone (acromegaly) and/or prolactin (prolactinoma);
(b) basophil adenoma (producing ACTH or LH or FSH) (overproduction of cortisol, Cushing disease);
(c) chromophobe adenoma which do not secrete hormones (e.g. non-functioning tumors).
Nowadays, the pathological classification of pituitary adenomas is based on the hormone content of the tumors using immuno-histochemical staining with antibodies.
(Stained sections kindly provided by P. Wesseling MD PhD, Head Neuropathology, Department of Pathology, Radboud university medical center, Nijmegen, The Netherlands)
Keywords/Mesh: adrenocortical adenoma, adrenal gland, pituitary, chromophobe adenoma, histology, pathology, POJA collection