12.1.7 POJA-L3379+3378+
3380.
Cortical cataract
12.1.7 POJA-L3379+3378+3380
Title: Cortical cataract
Description:
(A-C): Lens cataract, electron microscopy, human. Low magnification of cortical cataract (opacities in outer cortex up to 400-800 µm below surface) showing numerous normal slender elongated lens fibers (A, 1) with granular cytoplasm (C, 2) and the strong interlocking
of the cells. Local areas of swollen fibers filled with globules and vesicles (A, B, C 3) cytoplasm are also present.
(B): Higher magnifications reveal the presence of small and larger globules, empty vesicles of varying densities as well as tied-off small globular structures (C, 4) and folded membranes (C).
Background: Cataract is clouding of the lens causing opacities that obstructs the light to become focused on the retina (reduced transmission). Age-related cortical changes in the lens might start between the 2nd till 5th decade. Lens ageing is accompanied with increase in stiffness, light scattering and lens coloration. The equatorial superficial or deep lens cortex shows small opaque shades
which eventually grow out to segmental opacities. These shades are filled with small vesicles and contain abnormal amounts of proteins (cholesterol and phospholipids).
Cataract formation is considered as a result of a.o. oxidative stress as well as shear stress between the lens cortex and the central part (=nucleus) of the lens during accommodation.
Keywords/Mesh: eye, lens, cataract, age, histology, pathology, electron microscopy, POJA collection
Title: Cortical cataract
Description:
(A-C): Lens cataract, electron microscopy, human. Low magnification of cortical cataract (opacities in outer cortex up to 400-800 µm below surface) showing numerous normal slender elongated lens fibers (A, 1) with granular cytoplasm (C, 2) and the strong interlocking
of the cells. Local areas of swollen fibers filled with globules and vesicles (A, B, C 3) cytoplasm are also present.
(B): Higher magnifications reveal the presence of small and larger globules, empty vesicles of varying densities as well as tied-off small globular structures (C, 4) and folded membranes (C).
Background: Cataract is clouding of the lens causing opacities that obstructs the light to become focused on the retina (reduced transmission). Age-related cortical changes in the lens might start between the 2nd till 5th decade. Lens ageing is accompanied with increase in stiffness, light scattering and lens coloration. The equatorial superficial or deep lens cortex shows small opaque shades
which eventually grow out to segmental opacities. These shades are filled with small vesicles and contain abnormal amounts of proteins (cholesterol and phospholipids).
Cataract formation is considered as a result of a.o. oxidative stress as well as shear stress between the lens cortex and the central part (=nucleus) of the lens during accommodation.
Keywords/Mesh: eye, lens, cataract, age, histology, pathology, electron microscopy, POJA collection